Isotretinoin (Accutane®) is the most potent human teratogen (a teratogen interferes with the development of a fetus and causes birth defects).

Women who become pregnant while using isotretinoin have a high risk for pregnancy loss or for having babies with severe birth defects. These defects usually affect the development of the fetus’ brain, face, ears, thymus and heart.

If you, or someone you know, is pregnant and has used isotretinoin during pregnancy,
Please Call (Toll-Free) 1-866-626-6847.

The North American Isotretinoin Research Study is closed to recruitment. If you are interested in helping out by enrolling in a different OTIS pregnancy research study, please visit the Research Study Overview page.